Research Focus: Advancing Cancer Treatment Through Comparative Oncology

Cancer remains one of the most formidable health challenges of our time. 1 in 2 men and 1 in 3 women will be diagnosed with cancer in their lifetime, and the incidence of childhood cancers continues to rise. Additionally, 1 in 4 dogs and 1 in 5 cats will also face a cancer diagnosis, with dogs experiencing cancer at an even greater rate than humans.

Dogs share up to 85% of our DNA, making them uniquely positioned to help researchers uncover breakthroughs in cancer treatment. Because the most common cancers in dogs closely resemble those found in humans—especially childhood cancers—studying canine cancer allows scientists to accelerate discoveries that benefit both pets and people. This is the foundation of comparative oncology research, a field that bridges veterinary and human medicine to drive innovation in cancer treatment.

Our Vision: Driving Innovation in Cancer Research

Since 1999, the Animal Cancer Foundation (ACF) has been at the forefront of comparative oncology, funding pioneering research to find a cure for the millions of pets and people affected by cancer.

Our Work

· The Canine Cancer Genome Project (CCGP) – Sponsored by Blue Buffalo Foundation, this initiative is a multi-institutional effort led by TGen, Ethos Discovery, Tufts University, and CHOP. The project focuses on genomic and proteomic profiling of three critical canine cancers: osteosarcoma, B-cell lymphoma, and soft tissue sarcoma. By mapping the genetic mutations of these cancers and placing the datasets in the public domain, CCGP enables researchers to identify targeted treatments and develop personalized medicine for both dogs and humans.

· ACF Comparative Oncology Grant Awards – Early-stage funding for promising research that delivers near-term benefits for pets while advancing human cancer treatment.

· Meetings & Symposia Sponsorship – ACF fosters collaboration among leading cancer researchers, supporting organizations such as the Veterinary Cancer Society, Tufts Cancer Symposium, and the National Academy of Sciences.

Through these efforts, ACF continues to bridge the gap between veterinary and human oncology, ensuring that cancer research progresses in ways that benefit both species.

Together, we can transform cancer treatment and bring hope to millions.